WebCytotoxic T cell immunity in response to chronic infections and tumours is maintained by a specialized population of CD8+T cells that exhibit hallmarks of both exhausted and memory cells and give rise to terminally differentiated exhausted effector cells that contribute to viral or tumour control. WebJun 1, 2024 · CCR9+ CD8 T cells rapidly release CCL5 and significantly more than CCR9+ CD4 T cells. Conclusion: CCL5 is rapidly released upon activation, resulting in reduced intracellular expression. Reduced CCL5 expression by an elevated number of antigen-experienced CCR9-expressing CD8 T cells in pSS patients points towards increased …
KLF13 influences multiple stages of both B and T cell …
WebKLF2 orchestrates vascular homeostasis and serves as a key molecular switch between proinflammatory atheroprone and quiescent atheroresistant endothelial phenotype. This characteristic is attributed to its ability to activate atheroprotective and inhibit atherogenic endothelial transcription programs. WebAug 2, 2024 · A previous report indicated that deletion of Klf2 mediated by CD4Cre caused increased expansion or survival of thymic PLZF + T cells 34, and therefore promoted memory-like phenotype (CD44 hi ... coal tar ingredients
KLF13 sustains thymic memory-like CD8+ T cells in BALB/c mice …
WebJul 9, 2009 · The transcription factor KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P1 and the selectin CD62L. Recently, it was … WebPeripheral CD8 + T cells in Klf13 −/ ... KLF2 is expressed in quiescent T cells and is down-regulated soon after activation (Buckley et al., 2001; Kuo et al., 1997). In contrast, KLF13 is not expressed in resting T cells but is produced within 24–48 h of activation through the T cell receptor (Song et al., 2002). california jim wood