WebNov 25, 2010 · KLF2 (lung Krüppel-like factor) is expressed in lung, endothelial cells, and lymphocytes. 19–24 KLF2 deficiency is embryonic lethal because of severe hemorrhage resulting from defects in blood vessel integrity. 19 In T-cell biology, KLF2 has been demonstrated to regulate T-cell properties of quiescence, survival, activation, and … WebJul 17, 2009 · KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors The transcription factor KLF2 regulates T cell trafficking by promoting expression of the lipid-binding receptor S1P(1) and the selectin CD62L.
KLF2 transcription-factor deficiency in T cells results in …
WebSep 20, 2024 · These data suggest that TM cells in the blood can become more exhausted over time despite anti–PD-1 treatment, but ultimately the highest levels of exhaustion were in the tumor. We next quantified the extent to which the transcripts enriched in the TM component relative to the non-TM component correlated across patient samples. WebOct 6, 2024 · GEO help: Mouse over screen elements for information. Scope: Format: Amount: GEO accession: Series GSE179994. Query DataSets for GSE179994. Status. Public on Oct 06, 2024. Title. Temporal single cell tracing reveals clonal revival and expansion of precursor exhausted T cells during anti-PD-1 therapy in lung cancer. Organism. how has hershey changed
Early precursor T cells establish and propagate T cell exhaustion …
WebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as a bottle neck in the field of cancer immunotherapy have undoubtedly provoked attention. One of the main drivers of T cell exhaustion is prolonged antigen presentation, a prerequisite … WebOct 13, 2024 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. … WebNational Center for Biotechnology Information how has hipaa changed edi