WebFind technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes links to find associated … WebDescription: The purpose of this study is to evaluate the safety and tolerability, and determine the maximum tolerated dose of INCB062079 in subjects with advanced hepatocellular carcinoma and other malignancies. Related Conditions: Cholangiocarcinoma Esophageal Carcinoma Hepatocellular Carcinoma Malignant Solid Tumor Nasopharyngeal …
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WebFind technical definitions and synonyms by letter for drugs/agents used to treat patients with cancer or conditions related to cancer. Each entry includes links to find associated clinical trials. WebJul 1, 2024 · We describe the preclinical characterization of INCB062079 a potent and selective inhibitor of the FGFR4 kinase. In biochemical assays INCB062079 inhibited … how to sign up for shipt shopper
Open-Label Safety and Tolerability Study of INCB062079 in …
WebApr 26, 2024 · INCB062079 is a useful and discriminating irreversible inhibitor targeting FGFR4 (>250-fold vs. FGFR1/2/3) that suppresses the proliferation of HCC driven by increased expression of FGF19 (Ruggeri et al., 2024). Toxicological experiments are currently underway to investigate the safety and tolerability of INCB062079 in patients … WebMar 28, 2024 · AUC0-t of INCB062079 [ Time Frame: Protocol-defined time points during Cycles 1 and 2 of treatment, up to approximately 2 months per subject. Defined as area … WebTherapy Detail. Therapy Name. INCB062079. Synonyms. Therapy Description. INCB062079 is a selective FGFR4 inhibitor that prevents tumor cell proliferation in cells with amplification and overexpression of FGF19 (AACR; Cancer Res 2024;77 (13 Suppl):Abstract nr 1234, PMID: 32154250 ). Drugs 1. how to sign up for shiply