WebCancer Epigenetics and Stem Cell Biology Yan Lab Winter 2024 Our laboratory is interested in understanding how epigenetic aberrations cause cancer and other human diseases. In particular, we focus on the roles and regulatory mechanisms of histone demethylases from the JARID1/KDM5 protein family. WebOct 15, 2024 · Several studies have investigated whether aberrations in DNA methylation could be described as disease stage-specific, thus changing during disease progression …

Investigating pathological epigenetic aberrations by epi …

WebJan 30, 2024 · Although we focus in this Review on genetic aberrations, epigenetic modifications, cell signalling pathways and altered metabolism as cancer cell-intrinsic features that shape the cancer immune ... WebAug 24, 2024 · Epigenetic aberrations also possess the potential of changing gene expression and altering cellular functions. In the current study we assessed the landscape of DNA methylation aberrations during prolonged culturing of hPSCs, and defined a set of genes which are recurrently hypermethylated and silenced. the ocmulgee mounds

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WebRecently, amid the epigenetic therapies, histone deacetylase inhibitors (HDACIs) and DNA methyltransferase inhibitors have been used for treating tumors, either single or combined. Specifically, HDACIs are served as a good choice and deliver a novel pathway to treat GBM. WebEpigenetics appears to be a common denominator for hormonal and immunological aberrations in endometriosis. Epigenetics also appears to have a better explanatory power than genetics. There is accumulating evidence that various epigenetic aberrations exist in endometriosis. In vitro studies show that histone deacetylase inhibitors may be ... WebJan 20, 2024 · This type of epigenetic alteration has been implicated in numerous biological processes, such as cell differentiation, X-chromosome inactivation, embryogenesis and … the o.c. marissa death