WebBetter insight into the TFs that regulate macrophage polarization could provide novel therapeutic targets. Methods: IFN-γ (50 ng/mL) or IL4 (20 ng/mL) was utilized to … WebApr 4, 2024 · Irf1- and Egr1-activated transcription plays a key role in macrophage polarization: A multiomics sequencing study with partial validation. DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells. Egr1-EGFP transgenic mouse allows in vivo recording of Egr1 expression and neural activity.
Egr-1 Mediates Hypoxia-Inducible Transcription of the
WebMacrophage migration inhibitory factor is overproduced through EGR1 in TET2low resting monocytes Elodie Pronier 1,2,16, Aygun Imanci 1,3,16, Dorothée Selimoglu-Buet 1,3, Bouchra Badaoui4, Raphael ... WebNational Center for Biotechnology Information hydron collector
EGR1 Inhibits Pro-Inflammatory Gene Expression in …
WebJan 13, 2024 · EGR1 is essential for monopoiesis and binds enhancers that regulate monocytic developmental genes such as CSF1R . However, differentiating macrophages present a very different EGR1 binding... WebOct 1, 2024 · The most significantly highly expressed TFs in M1 and M2 macrophages were identified by RNA-seq as Irf1 and Egr1, with LogFC values of 3.2 and 2.8, respectively. Multiomic analyses further found that Irf1 regulated the transcription of 90 genes and that Egr1 regulated the transcription of 116 genes. WebAug 8, 2024 · Macrophages play pivotal roles in the progression and regression of atherosclerosis. Accumulating evidence suggests that macrophage polarization into an anti-inflammatory M2 state is a key ... mass general law chapter 184 section 31