WebSep 6, 2024 · Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the uncontrolled growth and proliferation of cancer cells. They are classified according to their mechanism of action and include. alkylating agents. , antimetabolites. , topoisomerase inhibitors. , antibiotics, mitotic inhibitors, and. WebAug 3, 2024 · Doxorubicin is believed to act on cancer cells by two different mechanisms: intercalation into DNA with disruption of topoisomerase II–mediated DNA repair, and generation of free radicals that result in damage to cellular membranes, DNA, and …
Doxorubicin - an overview ScienceDirect Topics
WebOct 27, 2024 · They are characterized by the presence of a wide range of derivatives, the most famous are doxorubicin and daunorubicin. The proposed action mechanism of anthracyclines and their derivatives to … WebApr 19, 2024 · In this review, we describe ROS-inducing cancer therapy and the anticancer mechanism employed by prooxidative agents. To understand the comprehensive biological response to certain prooxidative anticancer drugs such as 2-methoxyestradiol, buthionine sulfoximine, cisplatin, doxorubicin, imexon, and motexafin gadolinium, we propose and … spict positive
Doxorubicin induces an extensive transcriptional and …
WebDoxorubicin (DOX) is a potent anticancer drug with adverse cardiotoxic effects. Alginates are multifunctional biopolymers and polyelectrolytes derived from the cell walls … WebJan 19, 2024 · They have a threefold effect which accounts for their anticancer properties: 1. They form cross links between base pairs in the DNA double helix, stopping it from uncoiling and separating so replication cannot proceed. This mainly happens with guanine, although adenine and cytosine may also be affected. 2. Web(1)DOX has multiple mechanisms of action, including DNA intercalation, inhibition of topoisomerase II, generation of reactive oxygen species (ROS), and direct membrane effects; (2−4)however, its use can result in serious … spictygrid