Chimeric polynucleotide
WebDec 3, 2004 · The term “mutated or chimeric gene” is used to indicate that mutated or chimeric polynucleotides are obtained at a high frequency by using the method … WebInhibition depended on the number and type of modified internucleotide linkages: a 20-mer phosphorothioate ODN had an IC50 of 21 nM, while a chimeric ODN with seven phosphorothioate linkages and an identical sequence showed no inhibition.
Chimeric polynucleotide
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WebA Chimeric Antigen Receptor (CARs) may be introduced into a T cell in vitro to direct the T cell, once re- introduced into the subject, to selectively kill tumor cells based on expression of an... WebDec 4, 2024 · Chimeric nucleases enable genome editing in eukaryotic cell. Targeted genome editing with the hope of treating and curing diseases …
WebThe chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by... WebChimeric Polynucleotide Regions. In some embodiments, chimeric polynucleotides may be designed to comprise regions, subregions or parts which function in a similar …
WebThe polynucleotide sequence of the 2A peptide in the chimeric polynucleotide may be modified or codon optimized by the methods described herein and/or are known in the art. Notwithstanding the foregoing, the chimeric polynucleotides of the present invention may comprise a region or part which is not positionally modified or not chimeric as ... Web[0006] These studies are disclosed in, for example, Ribostem Limited in United Kingdom patent application serial number 0316089.2 filed on July 9, 2003 now abandoned, PCT applicat
WebThe chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by introducing into the cell of interest an isolated polynucleotide sequence encoding a chimeric TNFα that is expressed on the surface of the cell.
WebPatent US20160194625A1 - CHIMERIC POLYNUCLEOTIDES (US 20160194625A1); Owner: Moderna TX, Inc.; Filed: 09/03/2014; Published: 07/07/2016; Issued: ; Est. priority date: 09/03/2013; Status: Abandoned Application; Abstract: The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of … how do i scan a document to my email accountWebSep 26, 1995 · A chimera oligonucleotide is provided that can be used in a process for obtaining transcripts and/or amplification of a target sequence of a nucleic acid, ... An oligonucleotide sequence is called "DNA type" if it is comprised of DNA or if it is a modified polynucleotide sequence that, in addition to the nucleic acid strand hybridization ... how do i scan a file on my computerWebThe polynucleotide obtained in step (b) and a polynucleotide encoding the CyaC protein may be combined in a construct in such a way that following said combination, the obtained chimeric polynucleotide comprises or contains, from 5' end to 3' end, the polynucleotide construct of step (b) followed by a polynucleotide construct encoding a CyaC ... how do i scan a document into my computerWebFeb 10, 2024 · The method according to claim 1 comprising: (a) providing a first chimeric polynucleotide comprising as operably linked components: (i) a polynucleotide capable of controlling expression in the host cell; and (ii) a polynucleotide encoding a SLAM polypeptide; and (b) providing a second chimeric polynucleotide comprising as … how do i scan a flash driveWebThe chimeric polynucleotide may contain or encode one or more long noncoding RNA (IncRNA, or lincRNA) or portion thereof, a small nucleolar RNA (sno-RNA), micro … how much money is a golden bugattiWebThe chimeric protein can include a linker between the Bol3 polypeptide and the Lip5 polypeptide. The linker can be a polyhistidine linker. Also described is a polynucleotide encoding the chimeric protein, a vector incorporating the polynucleotide, and a host cell transformed with the vector. how much money is a gold pokemon card worthWebJul 7, 2016 · We claim: 1. A chimeric polynucleotide encoding a polypeptide, said chimeric polynucleotide having a sequence comprising Formula I, 5′[A n] x-L1-[B o] y-L2-[C p] z-L3 3′ I wherein: each of A and B independently comprise a region of linked nucleosides; C is an optional region of linked nucleosides; at least one of regions A, B, or … how do i scan a document to pdf in windows 10