WebDec 1, 2024 · BUB1, a mitotic serine/threonine kinase, has multiple functions in chromosome segregation, KT-MT interaction and SAC function [ 4, 5, 6 ]. It has been … WebDec 22, 2024 · BUB1, SER492TYR. rs121909055. RCV000007499. In a colorectal cancer cell line with chromosomal instability (see 114500) and loss of a mitotic checkpoint …
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WebApr 10, 2024 · Cryptococcus neoformans is an opportunistic, human fungal pathogen which undergoes fascinating switches in cell cycle control and ploidy when it encounters stressful environments such as the human lung. Here we carry out a mechanistic analysis of the spindle assembly checkpoint (SAC) which regulates the metaphase to anaphase … Mitotic checkpoint serine/threonine-protein kinase BUB1 also known as BUB1 (budding uninhibited by benzimidazoles 1) is an enzyme that in humans is encoded by the BUB1 gene. Bub1 is a serine/threonine protein kinase first identified in genetic screens of Saccharomyces cerevisiae. The protein is bound to kinetochores and plays a k… constitution of the effsc
Biallelic BUB1 mutations cause microcephaly, …
WebAug 4, 2009 · Here, we report that heterozygosity for a mutation in the mitotic checkpoint kinase gene, Bub1, induces a … Aneuploidy, the most common chromosomal abnormality at birth and the main ascertained cause of pregnancy loss in humans, originates primarily from chromosome segregation errors during oogenesis. WebBUB1 Gene - Somatic Mutations in Cancer Gene GRCh38 · COSMIC v97 Gene view The gene view histogram is a graphical view of mutations across BUB1. These mutations … WebJun 7, 2013 · BUB1 might have acted as a modifier gene in CRC development in this patient. Unfortunately, most parents of the BUB1 or BUB3 mutation carriers were … ed sheeran - shape of you text